Quaternized amines as sodium channel blockers

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专利权人:

Purdue Pharma L.P.

发明人:

Engel, John J.

申请号：

AU2012321111

公开号：

AU2012321111A1

申请日:

2012.10.30

申请国别(地区):

AU

年份:

2013

代理人:

摘要：

#$%^&*AU2012321111A120130516.pdf#####ABSTRACT The present disclosure provides substituted pyridine and pyrimidine compounds of Formula 1: A-X-A2 -Z-R 1 , and the pharmaceutically acceptable salts, solvates and prodrugs thereof, wherein A , X, A2, Z, and R are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.

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