Alfred Jonczyk;Wilfried Rautenberg;Wolfgang Stähle
发明人:
Wolfgang Stähle,Alfred Jonczyk,Wilfried Rautenberg
申请号:
US10573176
公开号:
US08242128B2
申请日:
2004.09.01
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The invention relates to compounds of formula 1, the production and use thereof as a medicament for the treatment of diseases, particularly tumours and/or diseases caused, mediated or propagated by angiogenesis. The compounds of formula 1 are effective inhibitors of tyrosin kinases, particularly TIE-2 and VEGFR, and Raf-kinases. (I)