An induced liver stem cell obtained by a method comprising a step of inducing a mammalian cell to an induced liver stem cell, wherein the mammalian cell is selected from the group consisting of a cell derived from an adult, a cell derived from neonate, a skin-derived cell and a cell of a cancerous individual, wherein said induction stage comprises introducing a POU5F1 gene, a KLF4 gene and a SOX2 gene into the mammalian cell with the help of expression vectors to carry the mammalian cell at a state such that the gene products of the POU5F1 gene, the KLF4 gene, and the SOX2 gene that are necessary for induction to the induced liver stem cell will be present to ensure that the relative intracellular abundance of the POU5F1 gene product is greater than that of the gene product of the SOX2 gene, where the ratio of use between the POU5F1 gene, the KLF4 gene and the SOX2 gene that are necessary for the Induced liver stem cell induction is 4: 2: 1 in that order, and where the induced liver stem cell is characterized in that it satisfies at least the following requirements (1) - (3): (1) expresses at least 15 genes selected from the group of genes listed in the following Table 1 which are marker genes for an embryonic stem cell； ** Table ** (2) has properties of a hepatocyte where at least genes selected from the gene group of Table 2 below they are expressed as genes associated with the properties of a hepatocyte； ** Table ** (3) can be subjected to an expansion culture or pass culture for at least 3 days.Una célula madre hepática inducida obtenida mediante un procedimiento que comprende una etapa de inducir una célula de mamífero a una célula madre hepática inducida, en donde la célula de mamífero se selecciona del grupo que consiste en una célula derivada de un adulto, una célula derivada de neonato, una célula derivada de la piel y una célula de un individuo canceroso, en donde dicha etapa de inducción comprende introducir un gen POU5F1, un gen KLF4 y un gen SOX2 en la
