The present invention relates to the treatment or prevention of P-selectin mediated disorders, and to anti-P-selectin antibodies or binding fragments thereof, for use in the treatment or prevention of such disorders. In particular, the invention relates to the treatment or prevention of pain crises associated with sickle cell disease, and to anti-P- selectin antibodies or binding fragments thereof, for use in the treatment or prevention of pain crises associated with sickle cell disease.本發明係關於P-選擇素媒介之病症之治療或預防,且係關於用於治療或預防此類病症之抗P-選擇素抗體或其結合片段。特定而言,本發明係關於與鐮狀細胞疾病相關聯之疼痛危象的治療或預防,且係關於用於治療或預防與鐮狀細胞疾病相關聯之疼痛危象的抗P-選擇素抗體或其結合片段。
