The present invention is directed to antibodies and fragments thereof having binding specificity for ACTH. Another embodiment of this invention relates to the antibodies binding fragments thereof described herein, comprising the sequences of the VH, VL and/or CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-ACTH antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention further contemplates methods of making said anti-ACTH antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-ACTH antibodies and binding fragments thereof for the diagnosis, assessment, prevention and treatment of diseases and disorders associated with ACTH, such as Cushing’s Disease, Cushing’s Syndrome, Parkinson’s disease, obesity, diabetes, sleep disorders depression, anxiety disorders, cancer, muscle atrophy, hypertension, hyperinsulinemia, cognitive dysfunction, Alzheimer’s disease, galactorrhea, stress related conditions, cardiac conditions, metabolic syndrome, hyperaldosteronism, Conn's syndrome and familial hyperaldosteronism.本發明係有關對ACTH具有結合特異性之抗體及其片段。本發明之另一實施例係關於本文所述之包含本文所述之VH、VL及/或CDR多肽之序列的其抗體結合片段以及編碼其之聚核苷酸。本發明亦涵蓋抗ACTH抗體及其結合片段結合於一或多種功能性或可偵測部分之結合物。本發明進一步涵蓋製備該等抗ACTH抗體及其結合片段之方法。本發明之實施例亦係關於抗ACTH抗體及其結合片段診斷、評估、預防及治療與ACTH相關之疾病及病症的用途，該等疾病及病症諸如庫欣氏病、庫欣氏症候群、帕金森氏病、肥胖症、糖尿病、睡眠障礙、抑鬱症、焦慮病症、癌症、肌肉萎縮、高血壓、高胰島素血症、認知功能障礙、阿茲海默氏病、乳溢、應激相關病狀、心臟病狀、代謝症候群、高醛固酮症、康氏症候群及家族性高醛固酮症。
