OLIGOSACCHARIDES ET CONJUGUES OLIGOSACCHARIDE-PROTEINE DERIVES D'UN POLYSACCHARIDE DE CLOSTRIDIUM DIFFICILE PS-II, PROCEDES DE SYNTHESE ET UTILISATIONS ASSOCIES, NOTAMMENT EN TANT QUE VACCIN
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V.
发明人:
SEEBERGER, PETER H.,OBERLI, MATTHIAS,HECHT, MARIE-LYN
申请号：
CA2828374
公开号：
CA2828374A1
申请日:
2012.03.07
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The present invention provides an oligosaccharide-protein conjugate comprising an oligosaccharide, in particular synthetic oligosaccharide, derived from the repeating unit of the Clostridium difficile glycopolymer PS-II and a protein carrier. More specifically, the oligosaccharide is the hexasaccharide having the following formula (I) wherein R is a linker or spacer group. In a specific embodiment of the invention, R is (CH2)nNH2, with n being an integer from 2 to 50. The present invention also provides the use of said oligosaccharide and said oligosaccharide-protein conjugate for the treatment or prevention of a disease caused by the pathogen Clostridium difficile. In still further aspects, the present invention also provides a favourable method for preparing said oligosaccharide and said oligosaccharide-protein conjugate.
