Oligosaccharides and oligosaccharide-protein conjugates derived from Clostridium difficile polysaccaride PS-I, methods of synthesis and uses thereof, in particular as vaccines and diagnostic tools
Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.
发明人:
Broecker, Felix,Anish, Chakkumkal,Seeberger, Peter H.,Martin, Christopher E.
申请号：
AU2012292430
公开号：
AU2012292430B2
申请日:
2012.07.30
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
The invention relates to a synthetic oligosaccharide representing part of the repeating unit of the Clostridium difficile glycopolymer PS-I and having the sequence of the pentasaccharide a-L-Rhap- ( 1→3 ) -β-D-Glcp- ( 1→4 ) - [a-L-Rhap- ( 1→3 ] -a-D-Glcp- ( 1→2 ) -a-D-Glcp or a synthetic fragment or derivative thereof. Preferably, the claimed synthetic oligosaccharide bears at least one linker L for conjugation to a carrier protein or for immobilization on a surface. Further aspects of the invention relate to advantageous methods for synthesizing said synthetic oligosaccharide and oligosaccharide-protein conjugate as well as to uses thereof, in particular as vaccines and diagnostic tools.
