Oligosaccharides et conjugués de protéine d'oligosaccharides dérivés de PS-I de polysaccharide difficile de Clostridium, procédés de synthèse et utilisations associées, en particulier en tant que vaccins et outils de diagnostic
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
发明人:
申请号：
EP11006355.9
公开号：
EP2554549A1
申请日:
2011.08.02
申请国别(地区):
EP
年份:
2013
代理人:
摘要：
The invention relates to a synthetic oligosaccharide representing part of the repeating unit of the Clostridium difficile glycopolymer PS-I and having the sequence of the pentasaccharide α-L-Rhap-(1→3)-β-D-Glcp-(1→4)-[α-L-Rhap-(1→3)]-α-D-Glcp-(1→2)-α-D-Glcp or a synthetic fragment or derivative thereof.Preferably, the claimed synthetic oligosaccharide bears at least one linker L for conjugation to a carrier protein or for immobilization on a surface.Further aspects of the invention relate to advantageous methods for synthesizing said synthetic oligosaccharide and oligosaccharide-protein conjugate as well as to uses thereof, in particular as vaccines and diagnostic tools.A preferred method for synthesizing the pentasaccharide is shown below.
