PROBLEM TO BE SOLVED: To provide a compound which specifically binds to GM1-bound Aβ (GAβ), specifically inhibits Aβ polymerization, and can inhibit amyloid fiber formation to provide an amyloid fibrogenesis inhibitor containing the compound and to provide a therapeutic or preventive agent for neurodegenerative disease.SOLUTION: The invention relates to an amyloid fibrogenesis inhibitor containing a compound represented by formula (I) or pharmaceutically acceptable salts or solvates thereof. [X is O or C Y is -CH2- or -C(O)- Z is -(CH2)l-C(O)-(CH2)m-NH-(CH2)n- or the like Ar is an aryl group or heteroaryl group R1 and R2 are each independently H, an alkyl group, alkoxyalkyl group, or the like where, R1 and R2 may form a ring jointly R3 is H, a halogen atom, alkyl group, cycloalkyl group, alkoxy group, or the like R4 is H, an alkyl group, hydroxyalkyl group, or the like.]SELECTED DRAWING: NoneCOPYRIGHT: (C)2016,JPO&INPIT【課題】GM1結合型Aβ(GAβ)に特異的に結合し、Aβの重合を特異的に阻害し、アミロイド線維の形成を抑制できる化合物、当該化合物を含むアミロイド線維形成抑制剤及び神経変性疾患の治療薬又は予防薬の提供。【解決手段】式(I)で表される化合物若しくはその薬学的に許容される塩又はそれらの溶媒和物を含んでなる、アミロイド線維形成抑制剤。[XはO又はC;Yは-CH2-又は-C(O)-;Zは-(CH2)l-C(O)-(CH2)m-NH-(CH2)n-等;Arはアリール基又はヘテロアリール基;R1及びR2は各々独立にH、アルキル基、アルコキシアルキル基等;ここで、R1及びR2は共同して環を形成してもよい;R3はH、ハロゲン原子、アルキル基、シクロアルキル基、アルコキシ基等;R4はH、アルキル基、ヒドロキシアルキル基等]【選択図】なし
