Glycosylated Form of Antigenic GLP-1 Analogue

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专利权人:

Kazuyuki Ishii;Yasuhiro Kajihara;Katsunari Tezuka;Takashi Tsuji;Kenta Yoshida;Yuri Nambu

发明人:

Yasuhiro Kajihara,Takashi Tsuji,Yuri Nambu,Kazuyuki Ishii,Kenta Yoshida,Katsunari Tezuka

申请号：

US13502723

公开号：

US20120264684A1

申请日:

2010.10.25

申请国别(地区):

US

年份:

2012

代理人:

摘要：

Disclosed is a glucagon-like peptide-1 (GLP-1) analogue which is obtained by ameliorating a highly antigenic GLP-1 analogue so that the GLP-1 analogue has reduced antigenicity without being lowered in the blood glucose suppressing activity. Specifically disclosed is a glycosylated form of an antigenic GLP-1 analogue, which has GLP-1 activity and is obtained by substituting at least one amino acid of an antigenic GLP-1 analogue with a glycosylated amino acid.

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