Glycosylated form of antigenic GLP-1 analogue

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专利权人:

Otsuka Chemical Co.; Ltd.

发明人:

Kajihara, Yasuhiro,Tsuji, Takashi,Nambu, Yuri,Ishii, Kazuyuki,Yoshida, Kenta,Tezuka, Katsunari

申请号：

AU2010312655

公开号：

AU2010312655A1

申请日:

2010.10.25

申请国别(地区):

AU

年份:

2012

代理人:

摘要：

Disclosed is a GLP-1 analogue which is obtained by ameliorating a highly antigenic GLP-1 analogue so that the GLP-1 analogue has reduced antigenicity without being lowered in the blood glucose suppressing activity.Specifically disclosed is a glycosylated form of an antigenic GLP-1 analogue, which has GLP-1 activity and is obtained by substituting at least one amino acid of an antigenic GLP-1 analogue with a glycosylated amino acid.

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