Nov postopek sinteze ivabradina in njegovih dodatnih soli s farmacevtsko sprejemljivo kislino

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专利权人:

LES LABORATOIRES SERVIER

发明人:

PEGLION JEAN-LOUIS,DESSINGES AIMEE,SERKIZ BERNARD,LERESTIF JEAN-MICHEL,LECOUVE JEAN-PIERRE,Peglion Jean-Louis,Dessinges Aimee,Serkiz Bernard,Lerestif Jean-Michel,Lecouve Jean-Pierre

申请号：

SI200930409

公开号：

SI2202225T1

申请日:

2009.12.23

申请国别(地区):

SI

年份:

2013

代理人:

摘要：

Preparing ivabradine compounds (VI) comprises reacting 3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-triene-7-carbaldehyde (VII) with an amine (VIII) in the presence of a reducing agent. Preparing ivabradine compounds of formula (VI) comprises reacting 3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-triene-7-carbaldehyde of formula (VII) with an amine of formula (VIII) in the presence of a reducing agent. A : CH 2CH 2 or CH=CH. An independent claim is also included for (VII) in racemic or optically active form. [Image] [Image] ACTIVITY : Cardiant； Antianginal； Antiarrhythmic. MECHANISM OF ACTION : None given.

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