LERESTIF, Jean-Michel,LECOUVE, Jean-Pierre,PEGLION, Jean-Louis,DESSINGES, Aimée,SERKIZ, Bernard
申请号：
MEP52612
公开号：
ME02037B
申请日:
2009.12.23
申请国别(地区):
ME
年份:
2013
代理人:
摘要：
Preparing ivabradine compounds (VI) comprises reacting 3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-triene-7-carbaldehyde (VII) with an amine (VIII) in the presence of a reducing agent. Preparing ivabradine compounds of formula (VI) comprises reacting 3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-triene-7-carbaldehyde of formula (VII) with an amine of formula (VIII) in the presence of a reducing agent. A : CH 2CH 2 or CH=CH. An independent claim is also included for (VII) in racemic or optically active form. [Image] [Image] ACTIVITY : Cardiant； Antianginal； Antiarrhythmic. MECHANISM OF ACTION : None given.
