Nowy sposób syntezy iwabradyny i jej soli addycyjnych z kwasem farmaceutycznie dopuszczalnym

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专利权人:

Les Laboratoires Servier

发明人:

PEGLION, JEAN-LOUIS,DESSINGES, AIMÉE,SERKIZ, BERNARD,LERESTIF, JEAN-MICHEL,LECOUVE, JEAN-PIERRE

申请号：

PL09290990

公开号：

PL2202225T3

申请日:

2009.12.23

申请国别(地区):

PL

年份:

2013

代理人:

摘要：

Preparing ivabradine compounds (VI) comprises reacting 3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-triene-7-carbaldehyde (VII) with an amine (VIII) in the presence of a reducing agent. Preparing ivabradine compounds of formula (VI) comprises reacting 3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-triene-7-carbaldehyde of formula (VII) with an amine of formula (VIII) in the presence of a reducing agent. A : CH 2CH 2 or CH=CH. An independent claim is also included for (VII) in racemic or optically active form. [Image] [Image] ACTIVITY : Cardiant； Antianginal； Antiarrhythmic. MECHANISM OF ACTION : None given.

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