PROSPECT CHARTERCARE RWMC; LLC D/B/A ROGER WILLIAMS MEDICAL CENTER
发明人:
KATZ, Steven C.,JUNGHANS, Richard
申请号：
HK18114889
公开号：
HK1255815A1
申请日:
2018.11.21
申请国别(地区):
HK
年份:
2019
代理人:
摘要：
The present disclosure provides compositions and methods for treating a peritoneal cancer in a subject. The methods include administering a T cell which is genetically modified to express a chimeric T cell receptor protein. The chimeric T cell receptor protein may include a T cell receptor signaling domain fused to the tumor associated antigen-binding fragment of an antibody or a T cell receptor signaling domain fused to a naturally occurring ligand which specifically binds to a tumor cell surface protein. The compositions and methods disclosed herein are therapeutically effective to reduce, for example, tumor burden, abdominal ascites, peritoneal mucin, or serum tumor marker levels.
