Combined human papillomavirus VLP/gene delivery system and use thereof as a vaccine for prophylaxis and immunotherapy of infectious diseases and tumors
Robert C. Rose;Christine Malboeuf;Young-Eun Ellen Lee
发明人:
Robert C. Rose,Christine Malboeuf,Young-Eun Ellen Lee
申请号：
US12439338
公开号：
US08778351B2
申请日:
2007.08.30
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to compositions that contain a chimeric papillomavirus virus-like particle (VLP) in combination with a DNA molecule encoding a protein or polypeptide epitope. The chimeric papillomavirus VLP is assembled from an L1 protein or polypeptide and a chimeric protein or polypeptide containing at least a portion of the L2 protein and a protein or polypeptide including an immunogenic epitope. The composition is useful for inducing an enhanced immune response against a pathogen or a tumor.
