EPITOPES DU PAPILLOMAVIRUS HUMAIN CIBLES PAR DES LYMPHOCYTES T INFILTRANT DES TUMEURS CERVICALES MALIGNES POUR UTILISATION EN TANT QUE VACCINS

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专利权人:

ACADEMISCH ZIEKENHUIS LEIDEN H.O.D.N. LUMC

发明人:

申请号：

EP08753802.1

公开号：

EP2152729B1

申请日:

2008.05.27

申请国别(地区):

EP

年份:

2013

代理人:

摘要：

The present invention relates to novel CD4+ and CD8+ T cell epitopes that are specific for HPV-specific E6 and E7 oncoproteins, to peptides comprising these novel T cell epitopes, and to (vaccine) compositions comprising these peptides for use in methods for the prevention and/or treatment of HPV related diseases. Preferred epitopes are recognized by a T cell that infiltrates a cervical neoplastic lesion or by a T cell from a draining lymph node, and are presented by an HLA-DQ or HLA-DP molecule, or an HLA-B.

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