A medicine injection device includes a header including a first connector configured to receive an electrical signal associated with a target analyte from a needle and configured to be connected to the needle, a medicine storage configured to be connected to the needle when the needle and the header are connected and store a medicine, a driver configured to apply an external force to the medicine storage, a controller configured to control the driver to measure an amount of the target analyte based on the received electrical signal, determine an injection amount in response to the measuring being completed, and inject the determined injection amount, and a notifier configured to receive, from the controller, measurement information associated with the amount of the target analyte and injection information associated with the injection amount and provide a user with the received measurement information and injection information.