The invention provides isolated monoclonal antibodies, in particular human monoclonal antibodies, which specifically bind to PD ￣ 1 with high affinity.Nucleic acid molecules encoding antibodies of the invention, expression vectors for expressing antibodies of the invention, host cells and methods are also provided.Immunoconjugates, bispecific molecules and pharmaceutical compositions containing antibodies of the invention are also provided.The invention also provides a method for detecting PD ￣ 1 by using anti PD ￣ 1 antibody, and a method for treating various diseases, including cancer and infectious diseases.The present invention further provides a method for treating hyperproliferative diseases, such as cancer, using a combination of combined immunotherapy such as anti CTLA ￣ 4 antibody and anti PD ￣ 1 antibody.The invention also provides methods for modifying adverse events associated with treatment with such antibodies alone.本發明提供了以高親和力與PD‑1特異性結合的分離的單克隆抗體，特別是人單克隆抗體。還提供了編碼本發明抗體的核酸分子、用於表達本發明抗體的表達載體、宿主細胞和方法。還提供了包含本發明抗體的免疫偶聯物、雙特異性分子和藥用組合物。本發明還提供了使用抗PD‑1抗體來檢測PD‑1的方法，以及治療各種疾病，包括癌症和傳染病的方法。本發明進一步提供了使用聯合免疫療法，諸如抗CTLA‑4抗體和抗PD‑1抗體的組合來治療過度增殖性疾病，諸如癌症的方法。本發明還提供了改變與單獨使用此類抗體進行的治療有關的不良事件的方法。
