The invention provides antibodies which bind to the extracellular domain of the Tyrosine-protein kinase transmembrane receptor Matriptase. Nucleic acid molecules encoding the antibodies, expression vectors, host cells and methods for expressing the antibodies are also provided. The antibodies may be used for the treatment of cancer, including gastric cancer, colorectal cancer, prostate cancer, breast cancer, ovarian cancer lung cancer, preferably SCLC, esophageal cancer, head and neck cancer, pancreatic cancer, lymphoma preferably non-Hodgkin’s lymphoma and skin cancer.本發明提供結合至酪胺酸-蛋白激酶跨膜受體間質蛋白酶之細胞外域的抗體。亦提供編碼該等抗體之核酸分子、用於表現該等抗體之表現載體、宿主細胞及方法。該等抗體可用於治療癌症,包括胃癌、結腸直腸癌、前列腺癌、乳癌、卵巢癌症、肺癌(較佳為SCLC)、食道癌、頭頸癌、胰臟癌、淋巴瘤(較佳為非霍奇金氏淋巴瘤)及皮膚癌。
