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2- (morpholin-4-yl) -1,7-naphthyridines
专利权人:
Bayer Pharma Aktiengesellschaft
发明人:
WORTMANN, Lars,LÜCKING, Ulrich,LEFRANC, Julien,BRIEM, Hans,KOPPITZ, Marcus,EIS, Knut,VON NUSSBAUM, Franz,BADER, Benjamin,WENGNER, Antje Margret,SIEMEISTER, Gerhard,BONE, Wilhelm,LIENAU, Philip,GRUDZIN
申请号:
ES15744596
公开号:
ES2679625T3
申请日:
2015.08.03
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A compound of general formula (I) ** (See formula) ** in which: R1 represents a group selected from: ** (See formula) ** in which * indicates the point of union of said group with the rest of the molecule; R2 represents hydrogen, halogen, -NR7R8, CN, C1-C6 alkyl, C1-C6 alkoxy, 3-10 membered heterocycloalkoxy, C2-C6 alkenyl, C3-C6 cycloalkyl, 3-10 membered heterocycloalkyl, heterocycloalkenyl of 4 to 10 members, phenyl, heteroaryl, - (CO) OR7, - (CO) NR7R8, - (SO2) R9, - (SO) R9, -SR9, - (SO2) NR7R8, -NR7 (SO2) R9, - ((SO)>; = NR11) R10, -N>; = (SO) R9R10, -SiR10R11R12, - (PO) (OR7) 2, - (PO) (OR7) R10 or - (PO) (R10) 2, in wherein each C1-C6 alkyl, C1-C6 alkoxy, 3-10 membered heterocycloalkoxy, C2-C6 alkenyl, C3-C6 cycloalkyl, 3-10 membered heterocycloalkyl, phenyl or heteroaryl optionally substituted, one or more times , independently of one another, with halogen, OH, -NR7R8, C1-C6 alkyl optionally substituted with hydroxyl or phenyl, C1-C6 haloalkyl, C1-C6 alkoxy, C3-C6 cycloalkyl, 3- to 6-membered heterocycloalkyl, phenyl, - (CO) OR7, - (CO) NR7R8, -NR7 (CO) R10, NR8 (CO) OR7, - NR8 (CO) NR7R8, - (SO2) R9, - (SO) R9, -SR9, - (SW 2) NR7R8, -NR7 (SO2) R9, - ((SO)>; = NR11) R10, -N>; = (SO) R9R10, - (PO) (OR7) 2, - (PO) (OR7) R10, - (PO) (R10) 2 or with a heteroaryl group that is optionally substituted, one or more times, with C1-C4 alkyl; wherein each 4-10 membered heterocycloalkenyl is optionally substituted, one or more times, independently of one another, with C1-C4 alkyl; R3, R4 independently represent one another, hydrogen or methyl; R7, R8 independently represent each other, hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl or phenyl, in which the phenyl is optionally substituted, one or more times, with halogen; or R7 and R8 together represent a cyclic amine group of 4, 5, 6 or 7 members, which is optionally substituted, one or more times, independently of one another, with a substituent selected from C1-C6 alkyl, C1-haloalkyl C6, wherein said 4, 5, 6 or 7-mem
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