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Prodrugs derived from substituted triazlopyridines
专利权人:
Bayer Pharma Aktiengesellschaft
发明人:
SCHULZE, Volker,LERCHEN, Hans-Georg,BIERER, Donald,WENGNER, Antje Margret,SIEMEISTER, Gerhard,LIENAU, Philip,KRENZ, Ursula,KOSEMUND, Dirk,STÖCKIGT, Detlef,BRÜNING, Michael,LÜCKING, Ulrich,TEREBESI, Il
申请号:
ES14728949
公开号:
ES2626790T3
申请日:
2014.06.06
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of general formula (I): ** Formula ** in which: RA represents a group selected from: - C (>; = O) - (CH2) 3-N (H) R3, - C (>; = O ) - (CR4R5) -N (R6) R7, - C (>; = O) -O- (CH2) 2-N (H) R3, - C (>; = O) -O- (CR4R5) -OP (>; = O) (OH) 2, - C (>; = O) -O- (CR4R5) -OC (>; = O) -R8, - C (>; = O) -O- (CR4R5) -OC (>; = O ) -CH (R6) -NH-C (>; = O) -R9; R1 represents a group selected from methoxy- and 2,2,2-trifluoroethoxy; R2 represents a group selected from: ** Formula ** in which "*" indicates the point of attachment to the phenyl ring to which R2 is attached; R3 represents a group selected from: C1-C6 alkyl, C3-C6 cycloalkyl, 4- and 7-membered heterocycloalkyl; said group being optionally substituted, one or more times, identically or differently, with a group selected from: -OH, -NH2, -N (H) R10, -N (R10) R11, -OP (>; = O) (OH) 2; R4 and R5, independently of each other, represent a group selected from a hydrogen atom and a C1-C3 alkyl group, or R4 and R5, together with the carbon atom to which they are attached, form a C3- cycloalkyl ring. C6; R6 represents a hydrogen atom or a C1-C3 alkyl group; R7 represents a hydrogen atom or a group -C (>; = O) R9; R8 represents a group selected from: C1-C6 alkyl, C3-C6 cycloalkyl, 4- and 7-membered heterocycloalkyl; said group being optionally substituted, one or more times, identically or differently, with a group selected from: -OH, -NH2, -N (H) R10, -N (R10) R11, -OP (>; = O) (OH) 2; R9 represents a group ** Formula ** or R9 represents a group selected from: ** Formula ** in which "**" indicates the point of attachment to the carbonyl group to which R9 is attached; R10 and R11, independently of each other, represent a group selected from a hydrogen atom and a C1-C3 alkyl group, or R10 and R11, together with the nitrogen atom to which they are attached form a heterocycloalkyl ring of between 4 and 7 members; R12 represents a group selected from a hydrogen atom, -OH, -NR10R11, -NH-C (>; = NH)
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