CRAWFORD, James John,ORTWINE, Daniel Fred,WEI, BinQing,YOUNG, Wendy B
申请号:
AU2019216728
公开号:
AU2019216728A1
申请日:
2019.08.16
申请国别(地区):
AU
年份:
2019
代理人:
摘要:
#$%^&*AU2019216728A120190905.pdf#####ABSTRACT Heteroaryl pyridone and aza-pyridone compounds of Formula I are provided, where one or two of X, X2, and X3 are N, and including stereoisomers, tautomers, and 5 pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed. RNH R4 Y2 O R Y k y1 ' R6 X1 -x3 X2 0 509