Hiroo Koyama,Ramil Baiazitov,Wu Du,Chang-sun Lee,Young-Choon Moon,Steven D. Paget,Hongyu Ren,Nadiya Sydorenko
申请号:
US15038039
公开号:
US09975878B2
申请日:
2013.11.21
申请国别(地区):
US
年份:
2018
代理人:
摘要:
Amine substituted triazine compounds and forms thereof that inhibit the function and reduce the level of B-cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein and methods for their use to inhibit Bmi-1 function and reduce the level of Bmi-1 to treat a cancer mediated by Bmi-1 are described herein.