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Fusion proteins and methods of use
专利权人:
发明人:
Langzhou Song,Ge Liu,Scott Umlauf,Uma Kavita,Hong Li,Xiangyu Liu,Bruce Weaver,Lynda Tussey
申请号:
US13931028
公开号:
US08932598B2
申请日:
2013.06.28
申请国别(地区):
US
年份:
2015
代理人:
摘要:
Compositions that include a fusion protein comprising flagellin and at least one antigen that has an isoelectric point greater than about 7.0 and that is fused to at least one domain 3 of the flagellin activate Toll-like Receptor 5. Methods of stimulating an immune response, in particular, a protective immune response include administering a composition that includes an antigen fused to a loop of domain 3 of flagellin.
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