WHELAN MICHAEL ANTHONY,FIELD ROBERT A,ROWLANDS DAVID J
申请号：
IN201727033562
公开号：
IN201727033562A
申请日:
2017.09.21
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
pqrThe invention provides a protein comprising hepatitis B core antigen (HBcAg) with a sequence of the formula XZX in an e1 loop wherein X is a negatively charged amino acid residue Z is a positively charged amino acid residue and p q and r are each independently an integer from 1 to 12 and wherein a sugar is attached to a Z residue. The protein may comprise a first and a second copy of HBcAg in tandem wherein one or both copies of HBcAg has a sugar attached to the e1 loop. The first copy may have a sugar attached to the e1 loop and the second copy may comprise a peptide epitope in the e1 loop. The protein may be used to induce an immune response against the sugar and hence act as a vaccine.
