Michael Anthony Whelan,Robert A. Field,David J. Rowlands
申请号：
US15560462
公开号：
US20180071384A1
申请日:
2016.03.24
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The invention provides a protein comprising hepatitis B core antigen (HBcAg) with a sequence of the formula XpZqXr in an e1 loop, wherein X is a negatively charged amino acid residue, Z is a positively charged amino acid residue, and p, q N and r are each independently an integer from 1 to 12, and wherein a sugar is attached to a Z residue. The protein may comprise a first and a second copy of HBcAg in tandem, wherein one or both copies of HBcAg has a sugar attached to the e1 loop. The first copy may have a sugar attached to the e1 loop and the second copy may comprise a peptide epitope in the e1 loop. The protein may be used to induce an immune response against the sugar and hence act as a vaccine.
