An adjustable acupoint and organ pressing device includes a rod, a first pressing member mounted on one end thereof, and an adjustment unit mounted on the other end thereof and provided with a second pressing member facing the first pressing member. The adjustment unit includes a frame and an adjustment handle hingedly connected to the frame with a spring in between. The adjustment unit also includes a fine-adjustment handle hingedly connected to the frame with a fine-adjustment plate and a fine-adjustment spring in between for fine adjustment.