SON, Jin Ryul,BAEK, Hyon Ho,LEE, Sung Wan,SONG, Min Gyu,CHA, Jae Uk,PARK, Eun Hee
申请号：
ES09849269
公开号：
ES2599968T3
申请日:
2009.10.13
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A process for the preparation of an enteric hard capsule, the process comprising: preparing an aqueous composition by dissolving an enteric base material, a capsule forming adjuvant, and a water neutralizing agent and maturing the solution at room temperature； preheat the aqueous composition to a first temperature that is lower than the gelation temperature for the aqueous composition； immersing in the aqueous composition a molded spike heated to a second temperature that is higher than the gelation temperature for the aqueous composition； extracting the molding pin from the aqueous composition to obtain a film formed on the molding pin； and preparing a capsule shell by keeping the film at a third temperature that is equal to or greater than the gelation temperature for the aqueous composition for a first period of time to fix the film on the molding pin and dry the film at a fourth temperature. during a second period of time, in which the first temperature is below the gelation temperature for the aqueous composition by 4 to 12.0 ° C； and wherein the second temperature is higher than the gelation temperature for the aqueous composition by 10 to 31 ° C； and in which the third temperature is in the range of 60 to 80 ° C, and the first period of time is in the range of 1 to 15 minutes.Un procedimiento para la preparación de una cápsula dura entérica, comprendiendo el procedimiento: preparar una composición acuosa mediante disolución de un material de base entérico, un adyuvante de formación de cápsulas, y un agente neutralizante en agua y madurar la solución a temperatura ambiente； precalentar la composición acuosa hasta una primera temperatura que es inferior a la temperatura de gelificación para la composición acuosa； sumergir en la composición acuosa una espiga de moldeo calentada hasta una segunda temperatura que es superior a la temperatura de gelificación para la composición acuosa； extraer la espiga de moldeo de la composición acuosa para obtener una película f
