The present invention provides a composition capable of treating cancer by specifically acting on anti-transmembrane protein 180 (TMEM-180), and a method for examining cancer comprising the step of measuring TMEM-180 in a sample As well as antibodies used therefor.本発明は、抗transmembrane protein 180(TMEM-180)に特異的に作用してがんを治療できる組成物を提供し、及び、試料中のTMEM-180を測定する工程を含むがんの検査方法を提供し、並びにこれらに用いる抗体を提供する。