COLON CANCER MODEL ANIMAL AND PRODUCTION METHOD OF THE SAME, ANTICANCER AGENT, ALLERGY MODEL ANIMAL AND PRODUCTION METHOD OF THE SAME, AND SCREENING METHOD
PROBLEM TO BE SOLVED: To provide a colon cancer model animal, a production method of the colon cancer model animal, an allergy model animal, a production method of the allergy model animal, and a screening method using the model animal.SOLUTION: A colon cancer model animal being a non-human animal is provided in which the function of the Gsdmd gene is missed or deteriorated. An allergy model animal being the non-human animal is provided in which the function of the Gsdmd gene is missed or deteriorated, and an allergic disease is easy to be developed. A production method of the model animal comprises a step of administering a colon cancer-specific carcinogen and a colon respiratory substance to the non-human animal in which the function of the Gsdmd gene is missed or deteriorated.SELECTED DRAWING: None【課題】大腸癌モデル動物の提供、該大腸癌モデル動物の製造方法、アレルギーモデル動物、アレルギーモデル動物の製造方法、及び該モデル動物を利用するスクリーニング方法を提供する。【解決手段】Gsdmd遺伝子の機能が欠損又は低下した非ヒト動物である大腸癌モデル動物。Gsdmd遺伝子の機能が欠損又は低下した非ヒト動物であり、アレルギー性疾患が発症されやすいアレルギーモデル動物。Gsdmd遺伝子の機能が欠損又は低下した非ヒト動物に、大腸癌特異的発癌物質及び大腸起炎物質を投与することを含む、モデル動物の製造方法。【選択図】なし