PREDICTING AGE-RELATED MACULAR DEGENERATION WITH SINGLE NUCLEOTIDE POLYMORPHISMS WITHIN OR NEAR THE GENES FOR COMPLEMENT COMPONENT C2, FACTOR B, PLEKHA1, HTRA1, PRELP, OR LOC387715
The invention relates to gene polymorphisms and genetic profiles associated with an elevated or a reduced risk of a complement cascade dysregulation disease such as AMD. The invention provides methods and reagents for determination of risk, diagnosis and treatment of such diseases. In an embodiment, the present invention provides methods and reagents for determining sequence variants in the genome of an individual which facilitate assessment of risk for developing such diseases.
