ФРЕЙЕР Сьюзан М. (US),МОНИЯ Бретт П. (US),ЧЖАН Хун (US),ЧЖАО Чэньгуан (US),КРОСБИ Джеффри Р. (US),СИВКОВСКИ Эндрю М. (US)
申请号：
RU2011119479/10
公开号：
RU2011119479A
申请日:
2009.10.15
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
1. A compound comprising a modified oligonucleotide consisting of 12-30 linked nucleosides and containing a nucleotide sequence comprising a portion of at least 8 adjacent nucleotide bases complementary to a portion of the nucleotide base sequence 1275-1318 of SEQ ID NO: 1 having the same length, wherein said nucleotide sequence of the modified oligonucleotide is at least 90% complementary to SEQ ID NO: 1.2. The compound according to claim 1, wherein said nucleotide sequence of the modified oligonucleotide is at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 100% complementary to the sequence of SEQ ID NO: 1.3. The compound according to claim 1 or 2, having: (i) a nucleotide sequence containing at least 8, at least 10, at least 12, at least 14, at least 16, at least 18 or 20 adjacent nucleotide base sequence SEQ ID NO: 223, 217, 51, 52, 53, 114, 115, 213, 214, 215, 216, 218, 219, 220, 221, 222, 224, 225, 226, 227, 228, 229, 230, 231, 232, 242, 243, 245, 246, 247, 248, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, 265, 266, 267, 268 or 269； or (ii) a nucleotide sequence containing at least 8, at least 10, at least 12, at least 14, at least 16, at least 18 or 20 adjacent nucleotide bases of the sequence SEQ ID NO: 223, 217 , 51, 52, 53, 114, 115, 213, 214, 215, 216, 218, 219, 220, 221, 222, 224, 225, 226, 227, 228, 229, 230, 231 or 232.4. The compound according to claim 1, having a nucleotide sequence containing at least 8, at least 10, at least 12, at least 14, at least 16, at least 18 or 20 adjacent nucleotide bases1. Соединение, включающее модифицированный олигонуклеотид, состоящий из 12-30 связанных нуклеозидов и содержащий нуклеотидную последовательность, включающую часть по меньшей мере из 8 смежных нуклеотидных оснований, комплементарных части последовательности нуклеотидных оснований 1275-1318 SEQ ID NO:1, имеющей такую же длину, где указанная нуклеотидная последовательность модифицированного олигону
