PROBLEM TO BE SOLVED: To provide a formulation suppressed in gastrointestinal tract disorders due to a nonsteroidal anti-inflammatory drug such as indomethacin, namely, a formulation which (i) stably keeps indomethacin in the gastric juice, (ii) suppresses gastrointestinal tract disorders, and besides (iii) efficiently transfers indomethacin from the gastrointestinal tract to blood.SOLUTION: There is provided a conjugate between a polymerized cyclic nitroxide radical compound and a non-steroidal anti-inflammatory drug, wherein the polymerized cyclic nitroxide radical compound is represented by general formula (I), PEG-CNR (wherein PEG is a poly(ethylene glycol)-containing segment, and CNR a polymer segment containing repeating units containing as a part of a pendant group a cyclic nitroxide radical bonded to the polymer main chain through a connecting group containing at least one ether bond), and the non-steroidal anti-inflammatory drug causes gastrointestinal tract disorders when orally administered.COPYRIGHT: (C)2013,JPO&INPIT【課題】インドメタシン等の非ステロイド性抗炎症薬に起因する消化管障害を抑制した製剤、すなわち、(i)胃液中ではインドメタシンを安定に保持し、(ii)かつ、消化管障害を抑制する、一方で、(iii)インドメタシンを消化管から血中に効率よく移行させる製剤の提供。【解決手段】高分子化環状ニトロキシドラジカル化合物と非ステロイド性抗炎症薬の複合体。【選択図】図1
