PROBLEM TO BE SOLVED: To provide an antiinflammatory agent which can suppress inflammatory reaction by various inflammatory mediators produced by inflammatory cells and infiltration of the inflammatory cells in inflammation parts, has no side effect, and has excellent antiinflammatory activity, and to provide a medicinal composition containing the antiinflammatory agent and effective in prevention or treatment of local inflammation.SOLUTION: The antiinflammatory agent contains a compound represented by general formula (1) or a salt thereof and suppresses activation of inflammatory cells. In the general formula (1), X denotes any of the substituents expressed by NHCOCF3, NHCOCCl3, NHC(=NH)NH2, or the like.COPYRIGHT: (C)2011,JPO&INPIT【課題】炎症性細胞が産生する種々の炎症性メディエーターによる炎症反応や、炎症局所における前記炎症性細胞の浸潤を抑制することができ、副作用がなく、優れた抗炎症活性を有する抗炎症剤、前記抗炎症剤を含有し、局所炎症の予防乃至治療に有効な薬用組成物の提供。【解決手段】下記一般式(1)で表される化合物乃至その塩を含有し、炎症性細胞の活性化を抑制する抗炎症剤。前記一般式(1)において、Xは、NHCOCF3、NHCOCCl3、NHC(=NH)NH2などで表される置換基のいずれかを示す。【選択図】なし
