Substituted Pyrazole and Pyrrole Compounds and Methods for Using Them for Inhibition of Initiation of Translation and Treatment of Diseases and Disorders Relating Thereto
M. Arshad Siddiqui,Stephane Ciblat,Martin Dery,Lea Constantineau-Forget,Chantal Grand-Maitre,Xiangyu Guo,Sanjay Srivastava,Gerald W. Shipps,Alan B. Cooper,Nicolas Bruneau-Latour,Vu Linh Ly
申请号：
US16748429
公开号：
US20200261424A1
申请日:
2020.01.21
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Disclosed are pyrazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structureand pharmaceutically acceptable salts and N-oxides thereof, wherein X1, X2, Z1, Z2, the ring system denoted by “a”, R1, A1A, L1B, A1B, L1A, L2, Q, L3, R3, A4A, L4B, A4B, L4A, R4, L5, and R5 are as described herein. In certain embodiments, compounds disclosed herein disrupt the eIF4E/eiF4G interaction, and can be used to treat hyperproliferative disorder, a neurological disease or disorder, or autism.
