Sun Joon Min,Yong Seo Cho,Ae Nim Pae,Eun Jeong Lim,Ji Yeong Kim,Myung Hee Son,Jae Kyun Lee
申请号：
US13943019
公开号：
US08946431B2
申请日:
2013.07.16
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Provided is a 2-(substituted ethynyl)quinoline derivative having an mGluR5 antagonistic activity and pharmaceutically acceptable salts thereof. The compound of the present invention can be useful as a medicament for treating and preventing mGluR5 receptor-mediated diseases such as Alzheimer's disease, senile dementia, Parkinson's disease, L-DOPA-induced dyskinesia, Huntington's chorea, amyotrophic lateral sclerosis, multiple sclerosis, schizophrenia, anxiety disorder, depression, neuropathic pain, drug dependence, fragile X syndrome, autism, migraine and gastroesophageal reflux disease (GERD).
