Substituted Pyrazole and Pyrrole Compounds and Methods for Using Them for Inhibition of Initiation of Translation and Treatment of Diseases and Disorders Relating Thereto
M. Arshad Siddiqui,Stephane Ciblat,Martin Dery,Lea Constantineau-Forget,Chantal Grand-Maitre,Xiangyu Guo,Sanjay Srivastava,Gerald W. Shipps,Alan B. Cooper,Nicolas Bruneau-Latour,Vu Linh Ly
申请号：
US15578585
公开号：
US20180311218A1
申请日:
2016.06.01
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Disclosed are pyrazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure (I) and pharmaceutically acceptable salts and/V-oxides thereof, wherein X1, X2, Z1, Z2, the ring system denoted by “a”, R1, A1A, L1B, A1B, L1A, L2, Q, L3, R3, A4A, L4B, A4B, L4A, R4, L5, and R5 are as described herein. In certain embodiments, compounds disclosed herein disrupt the elF4E/eiF4G interaction, and can be used to treat hyperproliferative disorder, a neurological disease or disorder, or autism.
