The Trustees of The University of Pennsylvania;Wayne State University
发明人:
JUNE, Carl H.,MILONE, Michael,ZHAO, Yangbing,LUM, Lawrence,THAKUR, Archana
申请号：
HK18116674
公开号：
HK1257441A1
申请日:
2018.12.27
申请国别(地区):
HK
年份:
2019
代理人:
摘要：
The present invention relates to compositions and methods for enhancing T cell metabolism and activity for more effective adoptive T cell therapy. By expressing an chimeric antigen receptor and bispecific antibodies in T cells, the T cells are metabolically enhanced with improved cytotoxicity and resistance to immunosuppression imposed by tumor microenvironments. Certain aspects include modified T cells and pharmaceutical compositions comprising the modified cells for adoptive cell therapy and treating a disease or condition associated with enhanced immunity.
