The Trustees of The University of Pennsylvania;Wayne State University
发明人:
申请号：
EP16842639.3
公开号：
EP3340998A4
申请日:
2016.08.25
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
The present invention relates to compositions and methods for enhancing T cell metabolism and activity for more effective adoptive T cell therapy. By expressing an intracellular signaling molecule in T cells, the T cells are metabolically enhanced with improved cytotoxicity and resistance to immunosuppression imposed by tumor microenvironments. One aspect includes a modified T cell and pharmaceutical compositions comprising the modified cells for adoptive cell therapy and treating a disease or condition associated with enhanced immunity.
