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신규한 퀴누클리딘 유도체 및 그것의 무스카린 엠3 수용체리간드로의 이용
专利权人:
发明人:
페르난데즈 포르너 돌러스,프래트 퀴논스 마리아,부일 알베로 마리아 안토니아
申请号:
KR10-2006-7027730
公开号:
KR10-0854315B9
申请日:
2006.12.28
申请国别(地区):
KR
年份:
2013
代理人:
摘要:
M3 muscarinic receptor (Hm3) with high affinity for the chemical formula i according to different compounds.(chemical formula i)in the method, thethe \u24d2 is not set, one or more heterogeneity in the c4 atom containing heterogeneity and the c9 aromatic compounds, and the mask is not out of the 5, 6, 7, 8 - you should not use the phenyl and naphthalene or costR1, R2 and R3 were independent of hydrogen or halogen atom, or the like to be recorded or not, and OR4 SR4, -, -, -, - NHCOR NR4R 5, 4, - 5, - CN CONR4R, NO2, -, - 4 and - CF3 COOR, or for example). so you know when to switch or select to return to the main chain or branch to display the chain lower alkyl, and each R5 R4 here is independent of the main chain is hydrogen atom, lower alkyl, or whether to display or printing, or with the family, or form or R1 and R2 and aromatic, with the \uc9c0\ud658 or heterogeneity to form. andn is 0 to 4, and from the essence ofa CH2 - -, - - - CR6 CR6 CH =, = - CR6R CH -, 7 -, - CO -, - 0 -, - s -, - s (0) -, or - SO2 NR6 - to display, and thus R6 R7 were independent of the hydrogen atom the main chain is broken, or not to display or lower alkyl, or R6 and R7 together form a ring), andm is from 0 to 8 of a constant, m is 0, a is - CH2 - is not.p is the essence of from 1 to 2, the nitrogen, the replacement of the asymmetric carbon of all possible structure containing two, three or four position can.)the type i), and b) to display the ii,.in the method, R10 hydrogen atom or methyl) are to be recorded, displayed, and R9 R8 of independentto display.in the method, R11 hydrogen or halogen atom, or the main chain or two chain lower alkyl or to display a single bond, q, - - - - - CH2, CH2 CH2 -, - o -, - o -, - s -, CH2 -, - s -, - or - CH2 CH, CH - display, conventional type i) or ii) that contains the key, they are what kind of the structure of the car, also can)x is a or the pharmaceutical science, and allows the display to be anion.무스카린 M3 리셉터(Hm3)에 대한 높은 친화성을 나타내는 화학식 I에 따르는 화합
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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