КАЙРАЛЛА Моис А. (US),БРИМ Гари (US),БУТТС Стивен Е. (US),МЕЛЬНИК СЮЗАН Мари (US),ТЕЙЛОР Дункан (US)
申请号：
RU2012101947/15
公开号：
RU2012101947A
申请日:
2010.06.21
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. A method for treating or preventing fatigue in a patient, comprising administering to a patient in need of treatment an effective amount for treating or preventing a compound of formula I or a pharmaceutically acceptable salt, ester or prodrug thereof, in which R represents an element selected from the group consisting of hydrogen, lower alkyl with 1-8 carbon atoms, a halogen selected from F, Cl, Br and I, alkoxyl with 1-3 carbon atoms, nitro group, hydroxyl, trifluoromethyl and thioalkoxyl with 1-3 carbon atoms； x is integer scrap from 1 to 3, provided that at x equal to 2 or 3, R may be the same or different； R and R may be the same or different, and they are independently selected from the group consisting of hydrogen, lower alkyl with 1-8 carbon atoms , aryl, heteroaryl, arylalkyl and cycloalkyl with 3-7 carbon atoms or R and R can be combined to form a 5-7 membered heterocycle substituted by elements selected from the group consisting of hydrogen, alkyl, aryl and heteroaryl groups, and the cyclic compound may contain 1-2 nitrogen atoms and 0-1 sour atom genus, and nitrogen atoms are not directly bonded to each other or to the oxygen atom. 2. The method according to claim 1, in which R represents hydrogen and x = 1.3. The method according to claim 1, in which all the groups R, R and R represent a hydrogen atom and x = 1.4. The method according to claim 1, wherein the compound of formula I has a structure or a pharmaceutically acceptable salt, ester or prodrug thereof. The method according to claim 1, wherein the compound of formula I is an enantiomer essentially free of other enantiomers, or a mixture of enantiomers in which one enantiomer predominates1. Способ лечения или профилактики усталости у пациента, включающий введение нуждающемуся в лечении пациенту эффективного для лечения или профилактики количества соединения формулы Iили его фармацевтически приемлемой соли, сложного эфира или пролекарства, в которойRпредставляет собой элемент, который выбирают из
