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СПОСОБ СИНТЕЗА СОЕДИНЕНИЙ ДИАРИЛТИОГИДАНТОИНА И ДИАРИЛГИДАНТОИНА
专利权人:
МЕДИВЭЙШН ПРОСТЕЙТ ТЕРАПЬЮТИКС; ИНК. (US)
发明人:
ДЖАИН Раджендра Парасмал (IN),АНЖЕЛО Реми (US),ТОМПСОН Эндрю (US),ЛАМБЕРСОН Кэрол (US),ГРИНФИЛД Скотт (US)
申请号:
RU2012140454/04
公开号:
RU2012140454A
申请日:
2011.02.24
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A process for preparing a compound of formula (I, 2-I) wherein X represents S or O Y and Ynezavisimo represent methyl or together with the carbon atom to which they are attached form a cycloalkyl group having 4-5 carbon atoms R a LC (= O) -NRRili L-CN wherein Lpredstavlyaet a single bond or C-alkylene iRi independently selected from H and C alkyl iRpredstavlyaet hydrogen or fluoro, comprising reacting a compound of formula Dgde R is C-alkyl with a compound of formula (F, 2-F) wherein X represents S or O, to give a compound diariltiogidantoina or diarilgidantoina of formula (I, 2-I) 2 . The method of claim 1, further comprising reacting the compound of formula Agde LG represents a leaving group, Br or I with a compound of the formula Su give compounds of formula Sivzaimodeystvie of formula C with a compound of formula R-LG or under alkylation conditions with a compound of formula R-OH in esterification conditions to form a compound of formula D3. A method according to claim 1, wherein X represents S.4. The method of claim 1 wherein Y and Yoba represent metil.5. The method of claim 1 wherein Y and Yvmeste with the carbon atom to which they are attached, combine to form a cyclobutyl or cyclopentyl ring koltsa.6. The method of claim 1, wherein a single Lpredstavlyaet svyaz.7. The method of claim 1 wherein R is -C (= O) -NHCH.8. The method of claim 1 wherein R is -C (= O) -NH.9. The method of claim 1, wherein R & F.10. The method of claim 1 wherein Y and Yoba are methyl, R is -C (= O) -NHCH, and R is F.11. The method of claim 1 wherein Y and Yoba are methyl, R is -C (= O) -NH, and R is F.12. A process for preparing a compound1. Способ получения соединения формулы (I,2-I)где X представляет собой S или ОY1 и Y2 независимо представляют собой метил или вместе с атомом углерода, к которому они присоединены, образуют циклоалкильную группу с 4-5 атомами углеродаR1 представляет собой L1-C(=O)-NR4R5 или L1-CN где L1 представляет собой одинарную связь или C1-С8алкилен иR4 и R5
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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