1 N t:T N O N 1-1 00 1-1 O N C (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 20 September 2018 (20.09.2018) WIP0 I PCT mu °million °nolo olomoliolommommo oimIE (10) International Publication Number WO 2018/170297 Al (51) International Patent Classification: A61K 35/00 (2006.01) A61K 39/09 (2006.01) A61K 35/16 (2015.01) A61K 39/155 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) (21) International Application Number: PCT/US2018/022701 (22) International Filing Date: 15 March 2018 (15.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 15/460,147 15 March 2017 (15.03.2017) US (71) Applicant: ADMA BIOLOGICS, INC. [US/US]； 465 Route 17 South, Ramsey, New Jersey 07446 (US). (72) Inventors: MOND, James； 465 Route 17 South, Ram- sey, New Jersey 07446 (US). GROSSMAN, Adam S.； 465 Route 17 South, Ramsey, New Jersey 07446 (US). (74) Agent: SISK, Tyler J.； Casimir Jones, S.C., 2275 Deming Way, Suite 310, Middleton, Wisconsin 53562 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (54) Title: ANTI-PNEUMOCOCCAL HYPERIMMUNE GLOBULIN FOR THE TREATMENT AND PREVENTION OF PNEU- MOCOCCAL INFECTION FIG. I Pneumococcal serotype specific IgG Concentrations in individual donor sera drawn at different time points Donor ID Time Point Sample ID Seroty c specific 1gG concentrat
