INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1#11101111 011101011M 0101111 1 0 I 011111011101110110110011110111 OEN Organization (10) International Publication Number International Bureau (43) International Publication Date .....0 WO 2017/196663 Al 16 November 2017 (16.11.2017) WIPO I PCT (51) (21) (22) (25) Filing Language: (26) (30) (71) (72) International Patent Classification: (74) Agent: PARLET, Nickki L. et al. Bristol-Myers Squibb CO7K 16/28 (2006.01) A61K 39/00 (2006.01) Company, Route 206 and Province Line Road, Princeton, New Jersey 08543 (US). International Application Number: PCT/US2017/031281 (81) Designated States (unless otherwise indicated, for every International Filing Date: kind of national protection available): AE, AG, AL, AM, 05 May 2017 (05.05.2017) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, English DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, Publication Language: English HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, Priority Data: MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, 62/333,470 09 May 2016 (09.05.2016) US PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, Applicant: BRISTOL-MYERS SQUIBB COMPANY TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. [US/US] Route 206 and Province Line Road, Princeton, New Jersey 08543 (US). (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, Inventors: PASHINE, Achal c/o Bristol-Myers Squibb GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, Company, Route 206 and Province Line Road, Princeton, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, New Jersey 08543 (US). CHEN, Guodong c/o Bristol-My- ers Squibb Company, Route 206 and Province Line Road, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE,
