HN L A -- R 3 H 2 N L-A-R 3 R 2 O L A -- R 3 L - A R - 3 (V) L - A R - 3 A . R 3 R (VI) H 2 N R 1 (VII) R 2 (Viii) R 2 N (IX) H 2 N (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 16 August 2018 (16.08.2018) WIPO I PCT ill 1111u°111110111sOHoI0 DIDIH1101IIIIIDiiIIII111111 DIIIIII (10) International Publication Number WO 2018/148626 Al (51) International Patent Classification: CO7D 471/04 (2006.01) A61K 31/501 (2006.01) C07F 9/09 (2006.01) A61K 31/4995 (2006.01) A61K 31/5377 (2006.01) A61K 31/4709 (2006.01) A61K 31/4545 (2006.01) A61K 31/55 (2006.01) A61K 31/506 (2006.01) A61P 29/00 (2006.01) A61K 31/444 (2006.01) (21) International Application Number: PCT/US2018/017755 (22) International Filing Date: 12 February 2018 (12.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/458,144 13 February 2017 (13.02.2017) US (71) Applicant: BRISTOL-MYERS SQUIBB COMPANY [US/US]； Route 206 and Province Line Road, Princeton, NJ 08543 (US). = (72) Inventors: GUO, Junqing； c/o Bristol-Myers Squibb Company, Route 206 and Province Line Road, Princeton, NJ 08543 (US). HART, Amy, C.； c/o Bristol-Myers Squibb Company, Route 206 and Province Line Road, Princeton, NJ 08543 (US). MACOR, John, E.； 55 Commanders Dri- ve, Washington Crossing, PA 18977 (US). MERTZMAN, Michael, E.； c/o Bristol-Myers Squibb Company, Route 206 and Province Line Road, Princeton, NJ 08543 (US). PITTS, William, J.； c/o Bristol-Myers Squibb Company, Route 206 and Province Line Road, Princeton, NJ 08543 (US). SPERGEL, Steven, H.； c/o Bristol-Myers Squibb Company, Route 206 and Province Line Road, Prince- ton, NJ 08543 (US). WATTERSON, Scott, Hunter； c/o Bristol-Myers Squibb Company, Route 206 and Province Line Road, Princeton, NJ 08543 (US). ANDAPPAN MU- RUGAIAH SUBBAIAH, Murugaiah； c/o Syngene In- ternational Limited, Biocon Special Econom
