DUBENSKY THOMAS W JR,KANNE DAVID B,LEONG MEREDITH LAI LING,GLICKMAN LAURA HIX,VANCE RUSSELL E,LEMMENS EDWARD EMILE
申请号：
IN8330/DELNP/2015
公开号：
IN2015DN08330A
申请日:
2015.09.14
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
The present invention provides highly active cyclic-di-nucleotide (CDN) immune stimulators that activate DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides induce STING-dependent type I interferon production, wherein the cyclic purine dinuclotides present in the composition are substantially pure 2, 5, 2, 5 and 2, 5, 3, 5 CDNs, and prefereably Rp,Rp stereosiomers thereof.
