KATIBAH GEORGE EDWIN,KANNE DAVID,SUNG LEONARD,GAUTHIER KELSEY,GLICKMAN LAURA HIX,LEONG JUSTIN,MCWHIRTER SARAH M,DUBENSKY JR THOMAS W
申请号：
IN201717029332
公开号：
IN201717029332A
申请日:
2017.08.18
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
The present invention provides highly active cyclic di nucleotide (CDN) immune stimulators that activate DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes) In particular the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides induce human STING dependent type I interferon production wherein the cyclic purine dinuclotides present in the composition are 2 fluoro substituted bis 3 5 CDNs and most preferably one or more 2 2 diF Rp Rp bis 3 5 CDNs.
