MENET, CHRISTEL JEANNE MARIE,MAMMOLITI, OSCAR,BLANC, JAVIER,ORSULIC, MISLAV,ROSCIC, MAJA
申请号：
CA2941474
公开号：
CA2941474A1
申请日:
2015.01.19
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The present invention discloses compounds according to Formula (I) wherein Cy, R1, L1 R3, R4, R5, La, and Ra are as defined herein. Novel benzimidazoles according to Formula (I), able to inhibit JAK are disclosed, these compounds may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, allergic diseases, inflammatory diseases, autoimmune diseases, proliferative diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6 or hypersecretion of interferons.
