MENET, CHRISTEL JEANNE MARIE,MAMMOLITI, OSCAR,BLANC, JAVIER,ORSULIC, MISLAV,ROSCIC, MAJA
申请号：
PL15701945
公开号：
PL3097083T3
申请日:
2015.01.19
申请国别(地区):
PL
年份:
2018
代理人:
摘要：
The present invention discloses compounds according to Formula I: Wherein Cy, R 1 , L 1 , R 3 , R 4 , R 5 , L a , and R a are as defined herein. Novel benzimidazoles according to Formula I, able to inhibit JAK are disclosed, these compounds may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, allergic diseases, inflammatory diseases, autoimmune diseases, proliferative diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6 or hypersecretion of interferons.
